MS641 MitoProfile Biogenesis Microplate
Assay Kit


$475.00 (96 tests)

Please contact us for volume discounts.


Brief Description & Uses

The MitoProfile Biogenesis Microplate Assay Kit is used to determine whether mitochondrial biogenesis has been up-regulated or down-regulated as a result of drug interactions or conditions such as oxidative stress and mitochondrial genetic disease.

MS641 is particularly suited for high-throughput screening of mitochondrial toxicity from antibiotic and antiviral drugs.

Compounds such as resveratrol and regimens such as caloric restriction have also been demonstrated to increase mitochondrial biogenesis in animal studies, and MS641 is suitable for studies of any such up-regulating factors in human cells or patient samples.

The principle of the assay is to compare the levels of Complex IV (cytochrome c oxidase), a mitochondrial enzyme which has 3 subunits encoded by mitochondrial DNA (mtDNA) and made by mitochondrial ribosomes, with that of frataxin, a mitochondrial protein encoded by nuclear DNA and made by cytosolic ribosomes.

Click here for a detailed overview of the biogenesis assay.

Also available is a POC version:
MS631 MitoProfile Biogenesis Dipstick Assay Kit


Specifications

Product: MitoProfile Biogenesis Microplate Assay Kit
Catalog #: MS641
Specificity: Human
Applications: For measuring inhibition of mitochondrial biogenesis in cultured cells or in human blood and tissue samples.
Storage: Store the AP reagent at -20C. When planning multiple experiments, aliquot AP reagent to prevent freeze-thaw cycles.
Store all other components at 4C.
Country of Origin: USA



Downloadable Information
MS641 Specifications


Related Products
MS631 MitoProfile Biogenesis Dipstick Assay Kit
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