MitoSciences is the leading developer of mitochondrial antibodies, mitochondrial assays, and products and services for mitochondrial toxicity screening. Our roots are in basic research and this orientation guides everything that we do. All of our products are supported by the scientists who develop them, and we have a 100% guarantee for everything that we sell.

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PDH and its regulatory proteins are becoming increasingly important targets for drug discovery and diagnostic applications. Our latest application guide, the PDH Playbook, provides a review of the enzyme, plus an overview of how PDH products from MitoSciences can be used for drug discovery, basic research, and biomarker development.

• Enzyme Activity Assay Kits in microplate and dipstick formats for both high-throughput and rapid measurement of the enzyme's functional state.

NEW Recombinant purified active PDH Kinases 1-4 and PDH Phosphatases 1 and 2 for fully-phosphorylating and dephosphorylating the enzyme after capture.

• Sandwich ELISA Assay Kits in microplate and dipstick formats for quantifying total PDH and phospho-PDH protein levels.

• Antibodies for WB and ICC against all four subunits of PDH.

• An Immunocapture Kit and Antibody Cocktail for isolating the enzyme on beads and for evaluating the subunit composition of the enzyme.

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NEW Diagrams illustrating key enzymes of metabolism.

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MitoNews is a free monthly annotated review of important publications in mitochondria and metabolic research.

• Complex II Enzyme Activity Microplate Assay Kit

• Cell Fractionation Kit HT

• MetaPath™ 4-Plex Dipstick Arrays

• SOD2 Protein Quantity Microplate Assay Kit

• Aconitase (ACO2) Enzyme Activity Microplate Assay Kit

• MetaPath™ Microplate Arrays

October 14, 2009 - MitoSciences announces that it is now under contract with 8 of the world's top 10 drug developers to provide mitochondrial toxicity screening services, or to help in the establishment of in-house screening standards.

October 1, 2009 - MitoSciences and LI-COR Biosciences have entered into a collaboration to develop novel In-Cell Western™ assays against mitochondrial and other metabolic targets.

July 15, 2009 - MitoSciences and EMD Biosciences are partnering to develop novel multiplexing assay panels.

May, 2009
Novel antibody-based strategies for the rapid diagnosis of mitochondrial disease and dysfunction.

May, 2009
Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization.

March, 2009
Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis.

January, 2009
Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues.