Enzymes > Apoptosis-Inducing Factor (AIF)
Apoptosis-Inducing Factor (AIF)
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UniProt Number:
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O95831
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Alternate Names:
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Apoptosis-inducing factor-like mitochondrion-associated inducer of death, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, p53-responsive gene 3 protein, PDCD8, COXPD6, MGC111425, AIFM1
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Structure and Function:
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Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner.
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Disease Associations:
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Deficiencies in AIF1 lead to combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. [MIM: 300816]
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Monoclonal Antibodies
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Cat. No.
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Name
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Reactivity
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Apps.
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Amount
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Price
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MSA09
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AIF antibody
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human
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WB, ICC, ICE, IP
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100 µg
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$325.00
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Protein Quantity Assays
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CART
