Proteins > Apoptosis-Inducing Factor (AIF)
Apoptosis-Inducing Factor (AIF)
|
UniProt Number:
|
O95831
|
|
Alternate Names:
|
Apoptosis-inducing factor-like mitochondrion-associated inducer of death, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, p53-responsive gene 3 protein, Programmed cell death protein 8, COXPD6, MGC111425, PDCD8, AIFM1
|
|
Structure and Function:
|
Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner.
|
|
Disease Associations:
|
Deficiencies in AIF1 lead to combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. [MIM: 300816]
|
Monoclonal Antibodies
|
Cat. No.
|
Name
|
Reactivity
|
Apps.
|
Amount
|
Price
|
|
|
MSA09
|
AIF antibody
|
human
|
WB, ICC, ICE, IP, FLOW
|
100 µg
|
$325.00
|
|
Protein Quantity Assays
|
Cat. No.
|
Name
|
Reactivity
|
Amount
|
Price
|
|
|
