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Vimentin
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UniProt Number:
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P08670
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Alternate Names:
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Structure and Function:
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Vimentin is a type III intermediate filament (IF) protein that that forms the cytoskeletal framework in the cytoplasm of eukaryotic cells. Other structural proteins such as actin and tubulin are highly conserved in different cell types, IF proteins are expressed in a highly tissue specific manner. Vimentin is the majority cytoskeletal protein in mesenchymal cells. Because of this vimentin is used as a marker of mesenchymally-derived cells or cells undergoing epithelial-to-mesenchymal transition (EMT) during normal development and metastatic progression.
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Disease Associations:
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Protein Quantity Assays
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