MSM02 Mitofilin monoclonal antibody
$295.00 (100 µg)
Please contact us for volume discounts.
This product can also be ordered as part of a sample pack.
Brief Description & Uses
100 µg of monoclonal antibody against mitofilin, suitable for use in
western blotting and immunocytochemistry. Isolated mitochondria are
available from several species for use as control samples. To see the
complete list of control samples available from MitoSciences, click here.
The mitofilin monoclonal antibody reacts against two isoforms
(approximately 90 and 91 kDa) in western blots with human heart
mitochondria. Theses two
isoforms of mitofilin appear in significant amounts in heart tissue,
but only the larger variant appears in human liver tissue. Often, a
number of slightly smaller bands are detected; this is not unusual for
mitochondrial proteins and indicates a ragged N-terminus.
Mitofilin is a transmembrane protein of the inner mitochondrial membrane and
is associated with a large multimeric protein complex of about 1200 kDa.
Mitofilin has critical functions in mitochondrial morphology and
mitochondrial fusion and fission, specifically in the formation of tubular
cristae and cristae junctions. Abnormal mitochondrial morphology has been
implicated in many human diseases such as myopathy, cardiomyopathy,
rhabdomyosarcoma and Whartin's tumor.
Specifications
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Product:
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Mitofilin monoclonal antibody
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Catalog #:
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MSM02
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Lot #:
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Clone ID:
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2E4AD5
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Host Species and Isotype:
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Mouse IgG1, κ
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Immunogen:
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Human heart mitochondria
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Concentration:
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1 mg/ml in HEPES-Buffered Saline (HBS) with 0.02% azide as a preservative.
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Purity:
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Near homogeneity as judged by SDS-PAGE. The antibodies were produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.
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Suggested Working Concentration:
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2 µg/ml for Western blotting; 1-5 µg/ml for immunocytochemistry
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Applications:
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Western blotting, immunocytochemistry
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Antigen Species Cross-Reactivity:
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human
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Storage:
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4°C
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Country of Origin:
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USA
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Product References
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References for Mitofilin
Images
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