MSM02 Mitofilin monoclonal antibody

$295.00 (100 g)

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Brief Description & Uses

100 g of monoclonal antibody against mitofilin, suitable for use in western blotting and immunocytochemistry. Isolated mitochondria are available from several species for use as control samples. To see the complete list of control samples available from MitoSciences, click here.

The mitofilin monoclonal antibody reacts against two isoforms (approximately 90 and 91 kDa) in western blots with human heart mitochondria. Theses two isoforms of mitofilin appear in significant amounts in heart tissue, but only the larger variant appears in human liver tissue. Often, a number of slightly smaller bands are detected; this is not unusual for mitochondrial proteins and indicates a ragged N-terminus.

Mitofilin is a transmembrane protein of the inner mitochondrial membrane and is associated with a large multimeric protein complex of about 1200 kDa. Mitofilin has critical functions in mitochondrial morphology and mitochondrial fusion and fission, specifically in the formation of tubular cristae and cristae junctions. Abnormal mitochondrial morphology has been implicated in many human diseases such as myopathy, cardiomyopathy, rhabdomyosarcoma and Whartin's tumor.


Product: Mitofilin monoclonal antibody
Catalog #: MSM02
Lot #:
Clone ID: 2E4AD5
Host Species and Isotype: Mouse IgG1, κ
Immunogen: Human heart mitochondria
Concentration: 1 mg/ml in HEPES-Buffered Saline (HBS) with 0.02% azide as a preservative.
Purity: Near homogeneity as judged by SDS-PAGE. The antibodies were produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.
Suggested Working Concentration: 2 g/ml for Western blotting; 1-5 g/ml for immunocytochemistry
Applications: Western blotting, immunocytochemistry
Antigen Species Cross-Reactivity: human
Storage: 4C
Country of Origin: USA

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References for Mitofilin


Downloadable Information
MSM02 Specifications Western Blotting Protocol Immunocytochemistry Protocol

Additional Information
Product Images
Product References
Protein References

Related Products
Western Blotting Controls

Secondary Antibodies
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