MS741 Dipstick Assay Kit for Human
Mitochondrial Trifunctional Protein

30 Dipstick Kit: $295.00
60 Dipstick Kit: $495.00
Please contact us for volume discounts.

Brief Description & Uses

Contains 30 or 60 dipsticks and necessary components to quantify the amount of the Mitochondrial Trifunctional Protein (MTP) from human sample material (rodent samples are not immuno-reactive). The kit includes sufficient materials to generate a standard curve and prepare twenty samples for analysis.

MTP is part of the mitochondrial fatty acid beta-oxidation pathway. It is located in the inner mitochondrial membrane and it catalyzes three out of the four steps in the beta-oxidation cycle with a specific affinity for long chain substrates. MTP is hetero-octamer composed of four α and four β-subunits. The α-subunit is a 79 kDa enzyme which has two enzymatic functions, the hydration of enoyl-CoA (E.C. and the dehydrogenation of 3-hydroxyacyl CoA (LCHAD - E.C. The β-subunit, a 47 kDa enzyme, performs the third function - the thiolytic cleavage of 3-ketoacyl-CoA substrates (E.C.

Inherited deficiency of MTP is a recessive genetic disease which occurs in approximately 1:38,000 newborns in the US. Deficiency of LCHAD (the dehydrogenase part of MTP) has also been found in children of women who develop HELLP syndrome (1:1,000 pregnancies) and AFLP syndrome (1:13,000 pregnancies), both of which are life-threatening obstetric conditions. Furthermore, heterozygous individuals for MTP defects are more susceptible to nonalcoholic hepatic steatosis, or nonalcoholic fatty liver disease (NAFLD), the most common form of liver disease in the US with a recorded prevalence as high as 39%.


Product: Dipstick Assay Kit for Human Mitochondrial Trifunctional Protein (MTP)
Catalog #: MS741
Kit Components: Dipsticks, dried MTP gold-conjugated antibody and buffers.
mAb Clone ID: 4A8BG12 (capture antibody on dipstick)
4D3AH11 (dried gold-conjugated in micro-titer plate)
Applications: Quantitative analysis of MTP levels
Antigen Species Cross-Reactivity: Human
Storage: Store dipsticks and gold-conjugated secondary antibody at room temperature out of direct sunlight in their provided containers. Store buffers at 4°C, or at -20°C for long term storage.
Country of Origin: USA

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References for Mitochondrial Trifunctional Protein (MTP)

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The above results show the accuracy and precision of the MTP dipstick kit (MS741) in measuring reduced amounts of MTP when a sample is diluted. HepG2 cell extract was diluted to 12.5% of the undiluted sample in 50% increments. Graphical analysis was performed using values interpolated from a standard curve. All analysis was done with the MS1000 dipstick reader and GraphPad software.

Downloadable Information
MS741 Mitochondrial Trifunctional protein MTP Assay Specifications protocol for MS740 Mitochondrial Trifunctional protein MTP Assay

Additional Information
Product Images
Product References
Protein References

Related Products
MS740 Rapid Microplate Assay for Human Mitochondrial Trifunctional Protein
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