MS702 Mitochondrial Trifunctional Protein
(TFP) Monoclonal Antibody

$295.00 (100 g)

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Brief Description & Uses

100 ug of monoclonal antibody reactive against the mitochondrial trifunctional protein (TFP). TFP is part of the mitochondrial fatty acid beta-oxidation pathway. It is located in the inner mitochondrial membrane and it catalyzes three out of the four steps in the beta-oxidation cycle with a specific affinity for long chain substrates. Inherited deficiency of TFP is a recessive genetic disease which occurs in approximately 1:38,000 newborns in the US. Deficiency of LCHAD (the dehydrogenase part of TFP) has also been found in children of women who develop HELLP syndrome (1:1,000 pregnancies) and AFLP syndrome (1:13,000 pregnancies), both of which are life-threatening obstetric conditions. Furthermore, heterozygous individuals for TFP defects are more susceptible to nonalcoholic hepatic steatosis, or nonalcoholic fatty liver disease (NAFLD), the most common form of liver disease in the US with a recorded prevalence as high as 39%.


Product: Mitochondrial Trifunctional Protein
(TFP) monoclonal antibody
Catalog #: MS702
Lot #:
Clone ID: 2C2AA5
Host Species and Isotype: Mouse IgG2b
Immunogen: Human Heart Mitochondria
Concentration: 1 mg/ml in HEPES-Buffered Saline (HBS) with 0.02% azide as a preservative.
Purity: Near homogeneity as judged by SDS-PAGE. The antibodies were produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.
Suggested Working Concentration: 0.5 g/mL for Western blotting
Applications: Western blotting, immunocapture
Antigen Species Cross-Reactivity: human
Storage: 4C
Country of Origin: USA

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References for Trifunctional Protein

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A Western blot image of MS702 with human heart mitochondria (HHM), and human liver mitochondria (HLM). An anti-Complex II 30kDa subunit antibody has been used as a control. MS702 also immunocaptures both the alpha and beta subunits of TFP.

Downloadable Information
MS702 Specifications Western Blotting Protocol Immunocapture Protocol

Additional Information
Product Images
Product References
Protein References

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