MS407 Complex IV subunit IV
monoclonal antibody

$295.00 (100 g)

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This product can also be ordered as part of a sample pack.

Brief Description & Uses

100 g of monoclonal antibody reactive against the 18 kDa COX (Complex IV) subunit IV. Reacts with human, bovine, mouse and rat. MS408 also labels to COX IV in immunocytochemical applications. Isolated mitochondria are available from several species for use as control samples. To see the complete list of control samples available from MitoSciences, click here.


Product: Complex IV subunit IV
monoclonal antibody
Catalog #: MS407
Lot #:
Clone ID: 20E8C12
Host Species and Isotype: Mouse IgG2a, κ
Immunogen: Bovine Complex IV (native holoenzyme protein, purified from liver)
Concentration: 1 mg/ml in HEPES-Buffered Saline (HBS) with 0.02% azide as a preservative.
Purity: Near homogeneity as judged by SDS-PAGE. The antibodies were produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation.
Suggested Working Concentration: 1.0 g/ml for Western blotting
Applications: Western blotting
Antigen Species Cross-Reactivity: human, bovine, mouse, rat and Zebrafish
Storage: 4C
Country of Origin: USA

Product References

J Clin Endocrin Metab. 2008 Jan 22; doi:10.1210/jc.2007-1701
"Activation of peroxisome proliferator activated receptor pathway stimulates the mitochondrial repiratory chain and can correct deficiencies in patients' cells lacking its components."

PloS One 2007 Oct;2(10):e1066.
"Hsp90 Inhibition Decreases Mitochondrial Protein Turnover."

Am. J. Physiol. - Endrocrin. Metab. 2007 July;293(3):e636.
"Responses of mitochondrial biogenesis and function to maternal diabetes in rat embryo during the placentation period ."

Cardiovas. Research. 2007 June;74(3):456-65.
"Caloric restriction and gender modulate cardiac muscle mitochondrial H2O2 production and oxidative damage."

J Bio. Chem. 2007 June;282(24):17557-62.
"An Assembled Complex IV Maintains the Stability and Activity of Complex I in Mammalian Mitochondria."

Neurosci. Letters 2007 Apr;416:160-4.
"Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner."

Hum Molec Genetics. 2007 Jan 8;16(4):431-44.
"Increased longevity and refractoriness to Ca2+ -dependent neurodegeneration in Surf1 knockout mice."

Invest. Ophthal. and Vis. Sci. 2007;48:991-1000.
"Skeletal Muscle of Female Rats Exhibit Higher Mitochondrial Mass and Oxidative- Phosphorylative Capacities Compared to Males."

Cell. Phys. and Biochem. 2007;19:205-12.
"Skeletal Muscle of Female Rats Exhibit Higher Mitochondrial Mass and Oxidative- Phosphorylative Capacities Compared to Males."

J Bioenerg Biomembr. 2006 Dec;38(5-6):283-91.
"Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex."

J Bio. Chem. 2006 Oct;281(41):30593-602.
"A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion."

J. Physiol. 2006 Sept;575(3):901-11.
"Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance."

J Biol Chem. 2006 June;281(22):15258-67.
"Tumor Necrosis Factor-induced Toxic Liver Injury Results from JNK2-dependent Activation of Caspase-8 and the Mitochondrial Death Pathway."

Am J Physiol Heart Circ Physiol. 2006 Jun 9
"Alterations in oxidative phosophorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6"

J. Struc. Bio. 2006 May;154(2):206-16.
"Structural organization of the perimysium in bovine skeletal muscle: Junctional plates and associated intracellular subdomains."

J Biol Chem. 2005 Sep 30;280(39):33588-98.
"Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency."

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References for Complex IV subunit IV

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Downloadable Information
MS407 Specifications Western Blotting Protocol Research Playbook

Additional Information
Product Images
Product References
Protein References

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