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Mitofilin
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UniProt Number:
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Q16891
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Alternate Names:
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mitochondrial inner membrane protein, p87/89, cell proliferation-inducing gene 4 protein, IMMT, HMP
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Structure and Function:
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Mitofilin is a transmembrane protein of the inner mitochondrial membrane and is associated with a large multimeric protein complex of about 1200 kDa. Mitofilin has critical functions in mitochondrial morphology and mitochondrial fusion and fission, specifically in the formation of tubular cristae and cristae junctions.
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Disease Associations:
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Abnormal mitochondrial morphology has been implicated in many human diseases such as myopathy, cardiomyopathy, rhabdomyosarcoma and Whartin's tumor.
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Monoclonal Antibodies
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