Electron transfer flavoprotein (ETF), mitochondrial

UniProt Number: alpha subunit: P13804
beta subunit: P38117
Alternate Names: ETF
Structure and Function: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). ETF is a heterodimer of an alpha and beta subunit.
Disease Associations: Defects in ETFA and ETFB are the cause of glutaric aciduria type 2A (GA2A) [MIM:231680]; also known as glutaricaciduria IIA. GA2A is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount
MS782 ETF subunit alpha (ETFA) antibody human, mouse, rat WB, ICC, IP, ICE, FLOW 100 µg

Protein Quantity Assays
Cat. No. Name Reactivity Amount
ab157395 Electron Transfer Flavoprotein Human ELISA Kit human 96 Tests

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