This novel array allows for the simultaneous quantification of 4 key enzymes whose expression is down-regulated in different mitochondrial disease patients: Complex I, Complex IV, PDH and Frataxin. The array is comprised of 4 monoclonal capture antibodies striped onto a dipstick, and the immunocaptured sample is detected using 4 monoclonal detector antibodies that recognize different epitopes on the target enzymes. This array is very rapid (total assay time including sample prep is less than 1 hour) and very sensitive, and as with all MitoSciences' assays, isolation of mitochondria is not required.

This array is suitable for testing a variety of sample types, including cultured cells and tissue from cheek swabs. Not only is it useful for measuring samples that are deficient in the 4 enzymes due to genetic mutations, it is also useful for measuring changes in the expression of the enzymes due to drug treatments or other manipulations.

Learn more about Dipstick Protein Quantity Assays >