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Dicarbonyl/L-xylulose reductase (DCXR)

UniProt Number: Q7Z4W1
Alternate Names: XR, l-xylulose reductase, kidney dicarbonyl reductase, carbonyl reductase II, sperm surface protein P34H, kiDCR
Structure and Function: DCXR is an oxidoreductase enzyme that catalyzes the NADPH-dependent reduction of several pentoses, tetroses, alpha-dicarbonyl compounds and L-xylulose. DCXR is part of the uronate cycle in glucose metabolism and is highly expressed in kidney and liver. Weak expression or not expressed in brain and heart tissue.
Disease Associations: Defects in DCXR are a cause of pentosuria [MIM: 260800]; also known as L-xylulosuria or xylitol dehydrogenase deficiency. Pentosuria is an inborn error of carbohydrate metabolism, characterized by the excessive urinary excretion of the sugar xylitol.

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount
MS704 DCXR antibody human WB, ICC, IP, ICE, FLOW 100 µg

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