Jump to Products:
• Monoclonal Antibodies >

Epoxide hydrolase 1 (EPHX1)

UniProt Number: P07099
Alternate Names: Microsomal epoxide hydrolase, Epoxide hydratase, EPHX, EPOX
Structure and Function: Epoxide hydrolases (also known as epoxide hydratases) function in detoxification during drug metabolism. They convert epoxides to trans-dihydrodiols, which can be conjugated and excreted from the body. Epoxides result from the degradation of aromatic compounds. The two best characterized forms are EPHX1, which is localized to the endoplasmic reticulum and microsome, and EPHX2, which is a cytosolic, so-called soluble, form of the enzyme.
Disease Associations: Genetic variation in EPHX1 may be associated with susceptibility to a form of pregnancy-induced hypertension known as pre-eclampsia [MIM:189800]. Defects in EPHX1 are a cause of familial hypercholanemia (FHCA) [MIM:607748]. Polymorphisms of EPHX1 influence susceptibility to COPD (Lee et al. 2010. Eur Respir J.).

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount
MS758 EPHX1 antibody human ICC, IP, ICE 100 µg

Browse Products By:
Product Search:

Related Pathways:

Xenobiotic Metabolism

Subscribe to MitoNews
MitoNews is a free periodic annotated review of important publications in mitochondria and metabolic research.

MitoNews Latest Issue
Volume 11 Issue 01 (February 2015)

MitoNews Archives

Sales & Customer Support:

[email protected]

© 2004-2022 MitoSciences Inc, an Abcam company. All rights reserved.