Proteins > Diablo homolog, mitochondrial (SMAC)
Diablo homolog, mitochondrial (SMAC)
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UniProt Number:
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Q9NR28
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Alternate Names:
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Second mitochondria-derived activator of caspase, DIABLO, Direct IAP-binding protein with low pI
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Structure and Function:
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SMAC (second mitochondrial derived activator of caspases), also called DIABLO (direct IAP-binding protein with low pI), often called Smac/DIABLO, is an inhibitor of a class of proteins involved in cell death called the IAPs or inhibitor of apoptosis proteins. Smac/DIABLO induced ubiquitinylation and subsequent degredation of c-IAP1 and c-IAP2. It is localized to mitochondria in dividing cells and released to the cytosol as an early step in mitochondrially triggered apoptosis
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Disease Associations:
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n/a
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Monoclonal Antibodies
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