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Diablo homolog, mitochondrial (SMAC)

UniProt Number: Q9NR28
Alternate Names: Second mitochondria-derived activator of caspase, DIABLO, Direct IAP-binding protein with low pI
Structure and Function: SMAC (second mitochondrial derived activator of caspases), also called DIABLO (direct IAP-binding protein with low pI), often called Smac/DIABLO, is an inhibitor of a class of proteins involved in cell death called the IAPs or inhibitor of apoptosis proteins. Smac/DIABLO induced ubiquitinylation and subsequent degredation of c-IAP1 and c-IAP2. It is localized to mitochondria in dividing cells and released to the cytosol as an early step in mitochondrially triggered apoptosis
Disease Associations: n/a

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount
MS715 SMAC antibody human ICC, FLOW 100 µg
MS719 SMAC antibody human WB 100 µg

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