Cytochrome c

UniProt Number: P99999
Alternate Names: CYC, CYCS
Structure and Function: Cytochrome c is a water-soluble mitochondrial intermembrane-space protein loosely attached to the inner mitochondrial membrane. It is approximately 13 kDa. It plays important roles in two processes: oxidative phosphorylation and apoptosis.

As an electron carrier in oxidative phosphorylation, cytochrome c shuttles four electrons, one at time, via its heme group from Complex III (cytochrome c reductase) to Complex IV (cytochrome c oxidase).

As a crucial player in apoptosis (programmed cell death), cytochrome c is released from the mitochondria to the cytosol where it binds to an adaptor subunit, APAF-1 in the presence of dATP, leading to activation of caspase 9. Caspase 9 triggers activation of other caspases which cleave and destroy other proteins. This results in cell death.
Disease Associations: Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4.

Because cytochrome c leaves the apoptotic cell following induction of apoptosis it is being increasingly recognized as a potentially useful circulating extracellular diagnostic and prognostic biomarker for disease conditions in which apoptosis is involved.

Review of potential cytochrome c biomarker applications.

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount Price  
MSA06 Cytochrome c antibody human, bovine, rat, mouse, C. elegans WB, ICC, ICE, FLOW 100 µg $325.00

Antibody Cocktails
Cat. No. Name Reactivity Amount Price  
MSA12 ApoTrack™ Cytochrome c Apoptosis WB Antibody Cocktail human 180 µg $425.00
MSA07 ApoTrack™ Cytochrome c Apoptosis ICC Antibody Kit human, bovine, rat, mouse, C. elegans 200 µg $425.00

Protein Quantity Assays
Cat. No. Name Reactivity Amount Price  
MSFX-16 Cytochrome c FlexPlex™ Module human, bovine 4 strips (32 tests) $125.00
MSA41 Cytochrome c Protein Quantity Microplate Assay Kit human, bovine, mouse, rat 96 tests $425.00

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