MitoSciences: Creatine kinase M-type (CKM), cytosolic

UniProt Number:	P06732
Alternate Names:	Creatine kinase M chain, M-CK, CKMM
Structure and Function:	Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phospho-creatine kinase, is an enzyme expressed by various tissues and cell types. CK reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa, since phosphocreatine serves as an energy reservoir for the rapid buffering and regeneration of ATP in situ, as well as for intracellular energy transport by the phosphocreatine shuttle or circuit.
Disease Associations:	Clinically, creatine kinase is assayed in blood tests as a marker of myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy, autoimmune myositides and in acute renal failure.