MitoSciences: Complex IV

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Proteins > Complex IV

Alternate Names:	cytochrome c oxidase, cytochrome oxidase, cytochrome c oxidoreductase
Structure and Function:	Complex IV is a complex of 13 different subunits, 3 of which (I, II and III) are encoded on mtDNA, with the remainder nuclear-encoded. The complex contains 2 heme groups (a and a3) and 2 copper atoms as prosthetic groups.
Disease Associations:	Genetic alterations of this enzyme complex are a common cause of OXPHOS diseases. The enzyme is altered in Alzheimer's disease, and there are reports of reduced amounts of this complex in cancer cells when these cells become hypoxic.

Monoclonal Antibodies

Cat. No.	Name	Reactivity	Apps.	Amount
MS401c	Complex IV capture antibody	Human, Bovine	IP	100 µg
MS404	Complex IV subunit I	Human, Bovine, Mouse, Rat, Zebrafish, C. elegans, oyster	WB, ICC, ICE, FLOW, BNPAGE	100 µg
ab154477	MTCO1 antibody (Alexa Fluor® 488)	Human, Bovine, Mouse, Rat, Zebrafish, C. elegans	ICC/IF, FLOW	100 µg
MS418	Complex IV subunit I (Cox1p)	S. cerevisiae	WB	100 µg
MS405	Complex IV subunit II	Human	WB, ICC, FLOW	100 µg
MS419	Complex IV subunit II (Cox2p)	S. cerevisiae	WB	100 µg
ab156031	MTCO2 [MM7D-5A11CA9] antibody	Human, Monkey	WB, ICC, Flow Cyt, IP	100 µg
MS406	Complex IV subunit III	Human, Rat, Mouse, S. cerevisiae	WB	100 µg
MS407	Complex IV subunit IV	Human, Bovine, Mouse, Rat, Zebrafish	WB, BNPAGE	100 µg
MS408	Complex IV subunit IV	Human, Bovine	WB, ICC, FLOW	100 µg
MS420	Complex IV subunit IV (Cox4p)	S. cerevisiae	WB	100 µg
MS409	Complex IV subunit Va	Human, Bovine, Mouse, Rat, Zebrafish	WB, ICC, FLOW	100 µg
MS410	Complex IV subunit Vb	Human, Bovine, Mouse, Rat	WB	100 µg
MS411	Complex IV subunit VIaH	Bovine	WB	250 µg
MS412	Complex IV subunit VIaL	Liver isoform in Human, Rat, Mouse	WB	250 µg
MS413	Complex IV subunit VIb	Human, Bovine, Rat	WB	100 µg
MS414	Complex IV subunit VIc	Human, Bovine, Rat	WB	100 µg
MS415	Complex IV subunit VIIaHL	Bovine, Rat	WB	250 µg
MS416	Complex IV subunit VIIb	Bovine	WB	250 µg
MS403	Complex IV subunit SURF1	Human	WB	100 µg

Protein Quantity Assays

Cat. No.	Name	Reactivity	Amount
ab124538	Cytochrome-C Oxidase (Complex IV) Human Profiling ELISA Kit (MS1038)	Human	96 Tests
MS443	Complex IV Human Duplexing (Activity + Quantity) Microplate Assay Kit	Human, Bovine	96 Tests
MS431	Complex IV Human Protein Quantity Dipstick Assay Kit	Human, Bovine	30 Tests
MS431	Complex IV Human Protein Quantity Dipstick Assay Kit	Human, Bovine	90 Tests

One Step Protein Quantity Assays

Cat. No.	Name	Reactivity	Amount
ab179880	Cytochrome-c Oxidase (Complex IV) Human ELISA Kit	Human	96 Tests

Enzyme Activity Assays

Cat. No.	Name	Reactivity	Amount
MS441	Complex IV Human Enzyme Activity Microplate Assay Kit	Human, Bovine	96 Tests
MS443	Complex IV Human Duplexing (Activity + Quantity) Microplate Assay Kit	Human, Bovine	96 Tests
MS444	Complex IV Rodent Enzyme Activity Microplate Assay Kit	Mouse, Rat	96 Tests
MS430	Complex IV Human Enzyme Activity Dipstick Assay Kit	Human, Bovine	30 Tests
MS430	Complex IV Human Enzyme Activity Dipstick Assay Kit	Human, Bovine	90 Tests
MS432	Complex IV Rodent Enzyme Activity Dipstick Assay Kit	Mouse, Rat	30 Tests
MS432	Complex IV Rodent Enzyme Activity Dipstick Assay Kit	Mouse, Rat	90 Tests

Multiplexing Arrays

Cat. No.	Name	Reactivity	Amount
MSX31	MetaPath™ MitoDisease 4-Plex Dipstick Array	Human	30 Tests
			90 Tests

Enzyme Purification Kits

Cat. No.	Name	Reactivity	Amount
MS401	Complex IV Human Immunocapture Kit	Human, Bovine	250 µg
			500 µg
			750 µg
MS402	Complex IV Rodent Immunocapture Kit	Mouse, Rat	250 µg
			500 µg
			750 µg

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Oxidative Phosphorylation

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