Complex I subunit NDUFS4 monoclonal antibody
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Catalog No. MS104
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$325.00 - 100 µg
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UniProt Number:
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O43181
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Alternate Names:
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NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, NADH-ubiquinone oxidoreductase 18 kDa subunit, Complex I-18 kDa, CI-18 kDa, Complex I-AQDQ, CI-AQDQ, NDUFS4
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Structure and Function:
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NDUFS4 is an 18-kDa subunit of Complex I, a 45-subunit complex of the respiratory chain. The NDUFS4 subunit makes up part of the iron-sulfur (IP) fragment of the protein. It has been claimed that the NDUFS4 subunit is phosphorylated in a cAMP dependent pathway that controls the activity of complex I. Mutations in this subunit, most often leading to loss of synthesis of the polypeptide, have been related to Complex I dysfunction in a number of patients with early onset mitochondrial diseases. It is thought that the subunit does not contribute to catalytic functions of Complex I. Useful in studies of Complex I assembly and Complex I deficiency in patients.
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Product Specifications
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Applications:
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Western blotting
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Species Reactivity:
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human, bovine, mouse, rat
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Host Species:
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mouse
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Isotype:
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IgG1, κ
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Clone ID:
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2C7CD4AG3
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Concentration:
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1 mg/mL in Hepes-Buffered Saline (HBS)-Buffered Saline (HBS) with 0.02% azide as a preservative.
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Suggested Working Concentration:
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1 µg/mL for Western blotting
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Storage Conditions:
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Store at 4°C. Do not freeze.
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Country of Origin:
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USA
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WB Images
(click to enlarge)
Figure 1. Isolated mitochondria from human heart (lane 1), bovine heart (lane 2), rat heart (lane 3), and mouse heart (lane 4), detected with (MS104) anti-NDUFS4 antibody.
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