MitoSciences: Complex I

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Proteins > Complex I

Alternate Names:	NADH dehydrogenase, NADH ubiquinone oxidoreductase
Structure and Function:	Complex I is a large protein complex of 950,000 MW made up of 45-46 different subunits. A total of 7 of the subunits of the complex are encoded on mtDNA, the remainder are nuclear encoded, made in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyses electron entry from NADH, as the name implies, via a flavin (FMN) and several non-heme iron centers.
Disease Associations:	Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson's disease and schizophrenia. Also there is evidence of Complex I involvement in diabetes.

Monoclonal Antibodies

Cat. No.	Name	Reactivity	Apps.	Amount
MS101c	Complex I capture antibody	Human, Mouse, Rat, Bovine	IP, ICC, ICE, FLOW	100 µg
MS109	Complex I subunit 8 kDa	Human, Mouse, Rat, Bovine	WB	100 µg
MS103	Complex I subunit GRIM-19	Human, Mouse, Rat, Bovine	WB, ICC, ICE, FLOW, BNPAGE	100 µg
MS111	Complex I subunit NDUFA9	Human, Mouse, Rat, Bovine	WB, BNPAGE	100 µg
MS107	Complex I subunit NDUFB4	Human, Rat, Bovine	WB, ICC, FLOW	100 µg
MS108	Complex I subunit NDUFB6	Human, Mouse, Rat, Bovine	WB	100 µg
MS105	Complex I subunit NDUFB8	Human, Mouse, Rat, Bovine	WB, BNPAGE	100 µg
MS114	Complex I subunit NDUFS2	Human	WB, ICC	100 µg
MS110	Complex I subunit NDUFS3	Human, Mouse, Rat, Bovine, Zebrafish	WB, ICC, IHC, FLOW	100 µg
MS112	Complex I subunit NDUFS3	Human, Mouse, Rat, Bovine, Zebrafish, Drosophila, C. elegans	WB	100 µg
MS104	Complex I subunit NDUFS4	Human, Mouse, Rat, Bovine	WB	100 µg

Enzyme Activity Assays

Cat. No.	Name	Reactivity	Amount
MS141	Complex I Enzyme Activity Microplate Assay Kit	Human, Mouse, Rat, Bovine	96 Tests
MS130	Complex I Enzyme Activity Dipstick Assay Kit	Human, Mouse, Rat, Bovine	30 Tests
MS130	Complex I Enzyme Activity Dipstick Assay Kit	Human, Mouse, Rat, Bovine	90 Tests

Protein Quantity Assays

Cat. No.	Name	Reactivity	Amount
ab124535	NADH Dehydrogenase (Complex I) Profiling ELISA Kit (MS1035)	Human, Bovine	96 Tests

ab136809	Complex I Rodent Profiling ELISA Kit	Human, Bovine	96 Tests

MS131	Complex I Human Protein Quantity Dipstick Assay Kit	Human, Bovine	30 Tests
			90 Tests
MS133	Complex I Rodent Protein Quantity Dipstick Assay Kit	Mouse, Rat	30 Tests
			90 Tests

One Step Protein Quantity Assays

Cat. No.	Name	Reactivity	Amount
ab178011	NADH dehydrogenase (Complex 1) Human ELISA Kit	Human	96 Tests

Multiplexing Arrays

Cat. No.	Name	Reactivity	Amount
MSX31	MetaPath™ MitoDisease 4-Plex Dipstick Array	Human	30 Tests
			90 Tests

Enzyme Purification Kits

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Volume 11 Issue 01 (February 2015)