Complex I


Alternate Names: NADH dehydrogenase, NADH ubiquinone oxidoreductase
Structure and Function: Complex I is a large protein complex of 950,000 MW made up of 45-46 different subunits. A total of 7 of the subunits of the complex are encoded on mtDNA, the remainder are nuclear encoded, made in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyses electron entry from NADH, as the name implies, via a flavin (FMN) and several non-heme iron centers.
Disease Associations: Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson's disease and schizophrenia. Also there is evidence of Complex I involvement in diabetes.


Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount
MS101c Complex I
capture antibody
Human, Mouse, Rat, Bovine IP, ICC, ICE, FLOW 100 µg
MS109 Complex I
subunit 8 kDa
Human, Mouse, Rat, Bovine WB 100 µg
MS103 Complex I
subunit GRIM-19
Human, Mouse, Rat, Bovine WB, ICC, ICE, FLOW, BNPAGE 100 µg
MS111 Complex I
subunit NDUFA9
Human, Mouse, Rat, Bovine WB, BNPAGE 100 µg
MS107 Complex I
subunit NDUFB4
Human, Rat, Bovine WB, ICC, FLOW 100 µg
MS108 Complex I
subunit NDUFB6
Human, Mouse, Rat, Bovine WB 100 µg
MS105 Complex I
subunit NDUFB8
Human, Mouse, Rat, Bovine WB, BNPAGE 100 µg
MS114 Complex I
subunit NDUFS2
Human WB, ICC 100 µg
MS110 Complex I
subunit NDUFS3
Human, Mouse, Rat, Bovine, Zebrafish WB, ICC, IHC, FLOW 100 µg
MS112 Complex I
subunit NDUFS3
Human, Mouse, Rat, Bovine, Zebrafish, Drosophila, C. elegans WB 100 µg
MS104 Complex I
subunit NDUFS4
Human, Mouse, Rat, Bovine WB 100 µg


Enzyme Activity Assays
Cat. No. Name Reactivity Amount
MS141 Complex I Enzyme Activity Microplate Assay Kit Human, Mouse, Rat, Bovine 96 Tests
MS130 Complex I Enzyme Activity Dipstick Assay Kit Human, Mouse, Rat, Bovine 30 Tests
90 Tests


Protein Quantity Assays
Cat. No. Name Reactivity Amount
ab124535 NADH Dehydrogenase (Complex I) Profiling ELISA Kit (MS1035) Human, Bovine 96 Tests
ab136809 Complex I Rodent Profiling ELISA Kit Human, Bovine 96 Tests
MS131 Complex I Human Protein Quantity Dipstick Assay Kit Human, Bovine 30 Tests
90 Tests
MS133 Complex I Rodent Protein Quantity Dipstick Assay Kit Mouse, Rat 30 Tests
90 Tests


One Step Protein Quantity Assays
Cat. No. Name Reactivity Amount
ab178011 NADH dehydrogenase (Complex 1) Human ELISA Kit Human 96 Tests


Multiplexing Arrays
Cat. No. Name Reactivity Amount
MSX31 MetaPath™ MitoDisease
4-Plex Dipstick Array
Human 30 Tests
90 Tests


Enzyme Purification Kits
Cat. No. Name Reactivity Amount
MS101 Complex I Immunocapture Kit Human, Mouse, Rat, Bovine 250 µg
500 µg
750 µg



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Apoptosis




Oxidative Phosphorylation


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