Mitochondria and Cancer

Mitochondrial involvement in cancer is at several levels. Genetic alterations in OXPHOS genes can predispose to cancer, as in the case of succinate dehydrogenase subunit mutations, which cause paraganglioma syndromes.

Also, metabolic changes in energy metabolism are characteristic of cancer as tumors switch from an OXPHOS mode to glycolysis as source of ATP production. Further, the organelle is a key part of the signaling in apoptosis, a process that must be down regulated to allow cell proliferation in the disease.

Finally, recent work indicates that there is recruitment of mitochondrial proteins to the plasma membrane of cancer cells. This is shown in the figure above. The red spots distributed over the surface of the cell are ATP synthase molecules stained with our antibody against ATP synthase subunit alpha (catalog no. MS502) while the green is mitochondrial reticulum identified with matrix-located green fluorescent protein.

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount Price  
MS201c Complex II capture antibody human, mouse, bovine IP 100 µg $325.00
MS203 Complex II subunit 30 kDa Ip human, mouse, rat, bovine, zebrafish WB, ICC 100 µg $355.00
MS204 Complex II subunit 70 kDa Fp human, mouse, rat, bovine, C. elegans WB, ICC, ICE, BNPAGE 100 µg $355.00

Protein Quantity Assays
Cat. No. Name Reactivity Amount Price  
MSFX-2 Complex II FlexPlex™ Module human 4 strips (32 tests) $125.00

Enzyme Activity Assays
Cat. No. Name Reactivity Amount Price  
MS241 Complex II Enzyme Activity Microplate Assay Kit human, rat, mouse, bovine 96 tests $425.00

Antibody Cocktails
Cat. No. Name Reactivity Amount Price  
MS202 Complex II WB Antibody Cocktail human, mouse, rat, bovine 305 µg $425.00
610 µg $745.00

Enzyme Purification Kits
Cat. No. Name Reactivity Amount Price  
MS201 Complex II Immunocapture Kit human, mouse, rat, bovine 250 µg $375.00
500 µg $675.00
750 µg $875.00

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