MitoSciences: ATP synthase

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Proteins > ATP synthase

Alternate Names:	Complex V, F1F0 ATPase
Structure and Function:	ATP synthase is responsible for ATP production in oxidative phosphorylation and can work in reverse as a proton pumping ATPase. The enzyme was thought to be localized exclusively to mitochondria. However, it has recently been identified also on the plasma membrane of several cell types including hepatocytes where it is the HDL receptor, and on endothelial cells where it may act as the angiostatin receptor. The enzyme in mammals is composed of 17 subunits, 5 of which make up the easily detached F1. The remainder are components of 2 stalk domains and the proton pumping F0 part of the machinery. Two of the subunits of the F0 part are encoded on mtDNA while the other subunits are nuclear encoded.
Disease Associations:	Mutations in the mt-encoded subunits of ATP synthase (Complex V) cause OXPHOS disease. ATP synthase has also been found on the surface of cancer cells.

Monoclonal Antibodies

Cat. No.	Name	Reactivity	Apps	Amount
MS501c	ATP synthase capture antibody	Human, Mouse, Rat, Bovine	IP	100 µg
MS502	ATP synthase subunit alpha antibody	Human, Mouse, Rat, Bovine, Zebrafish	WB, ICC, FLOW	100 µg
MS507	ATP synthase subunit alpha antibody	Human, Bovine, Rat, Mouse, Drosophila, C. elegans, Oyster	WB, ICC, FLOW, BNPAGE	100 µg
ab119688	ATP synthase subunit alpha antibody FITC conjugate	Human, Bovine, Rat, Mouse, Drosophila, C. elegans, Oyster	WB, ICC, FLOW, BNPAGE	100 µg
MS503	ATP synthase subunit beta antibody	Human, Mouse, Rat, Bovine, C. elegans	WB, ICC, ICE, FLOW	100 µg
MS511	ATP synthase subunit F1F0 beta antibody	Human, Bovine, E. coli	WB	100 µg
ab119686	ATP synthase subunit gamma antibody	Human, Bovine, Rat, Mouse	WB, ICC, ICE, FLOW, IP	100 µg
MS504	ATP synthase subunit d antibody	Human, Mouse, Rat, Bovine	WB, ICC, FLOW	100 µg
MS508	ATP synthase subunit F6 antibody	Human	WB, ICC, FLOW	100 µg
MS506	ATP synthase subunit IF1 antibody	Human, Mouse, Rat, Bovine	WB	100 µg
MS505	ATP synthase subunit OSCP antibody	Human, Bovine	WB, ICC, FLOW	100 µg
MS972	ATP synthase b subunit antibody	Human, Bovine	WB, ICC, FLOW	100 µg
ab173006	ATP synthase subunit d antibody	Human, Mouse, Rat, Bovine, Cow, African Green Monkey	WB, ICC, FLOW	100 µg
ab174438	ATP synthase subunit F-ATPase delta antibody	Mouse, Rat, Cow	WB	100 µg

Enzyme Activity Assays

Cat. No.	Name	Reactivity	Amount
MS541	ATP synthase Enzyme Activity Microplate Assay Kit	Human, Rat	96 Tests
MS543	ATP synthase Activity+Quantity Duplexing Microplate Assay Kit	Human, Rat	96 Tests

Western Blot Cocktails

Cat. No.	Name	Reactivity	Amount
ab139415	Endoplasmic Reticulum Fraction Western Blot Cocktail	Human, Rat	96 Tests

Protein Quantity Assays

Cat. No.	Name	Reactivity	Amount
ab124539	ATP Synthase (Complex V) Human Profiling ELISA Kit (MS1039)	Human	96 Tests
MS543	ATP synthase Activity+Quantity Duplexing Microplate Assay Kit	Human, Rat	96 Tests

Enzyme Purification Kits

Cat. No.	Name	Reactivity	Amount
MS501	ATP synthase Immunocapture Kit	Human, Mouse, Rat, Bovine	250 µg
			500 µg
			750 µg

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Oxidative Phosphorylation

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Volume 11 Issue 01 (February 2015)