Apoptosis-Inducing Factor (AIF)

UniProt Number: Q9BRQ8
Alternate Names: Apoptosis-inducing factor-like mitochondrion-associated inducer of death, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, p53-responsive gene 3 protein
Structure and Function: AIF is a flavoprotein (67 kDa) localized in the inter-membrane space. It is a multi-functional protein with a vital oxidoreductase function (required for cell survival), an anti-oxidant activity, an assembly function in Complex I (NADH-ubiquinone oxidoreductase complex) formation and an apoptogenic function. AIF has a major role in the caspase-independent apoptosis process. It translocates to the nucleus after mitochondrial release, leading to chromatin condensation and DNA fragmentation. Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length
Disease Associations: The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. AIF is down-regulated in a wide range of human tumors.

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount Price
MSA09 AIF antibody human WB, ICC 100µg $295.00

Protein Quantity Assays
Cat. No. Name Reactivity Amount Price
MSA42 AIF Protein Quantity
Microplate Assay Kit
human 96 tests $375.00
MSA31-30 AIF Protein Quantity
Dipstick Assay Kit
human 30 tests $325.00
MSA31-60 AIF Protein Quantity
Dipstick Assay Kit
human 60 tests $545.00

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