Proteins > Apoptosis-Inducing Factor (AIF)
Apoptosis-Inducing Factor (AIF)
|
UniProt Number:
|
Q9BRQ8
|
|
Alternate Names:
|
Apoptosis-inducing factor-like mitochondrion-associated inducer of death, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, p53-responsive gene 3 protein
|
|
Structure and Function:
|
AIF is a flavoprotein (67 kDa) localized in the inter-membrane space. It is a multi-functional protein with a vital oxidoreductase function (required for cell survival), an anti-oxidant activity, an assembly function in Complex I (NADH-ubiquinone oxidoreductase complex) formation and an apoptogenic function. AIF has a major role in the caspase-independent apoptosis process. It translocates to the nucleus after mitochondrial release, leading to chromatin condensation and DNA fragmentation. Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length
|
|
Disease Associations:
|
The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. AIF is down-regulated in a wide range of human tumors.
|
Monoclonal Antibodies
|
Cat. No.
|
Name
|
Reactivity
|
Apps.
|
Amount
|
Price
|
|
|
MSA09
|
AIF antibody
|
human
|
WB, ICC
|
100µg
|
$295.00
|
|
Protein Quantity Assays
|
CART
