Alzheimer's Disease


The involvement of mitochondria in Alzheimer's Disease has been known for many years with reduced cytochrome c oxidase (Complex IV) assembly and activity considered as an early event in the disease, and reduced cytochrome c oxidase activity has been reported in platelets from patients with Alzheimer's Disease.

Recent studies begin to explain mitochondrial involvement. The Alzheimer's amyloid precursor protein has now been localized to mitochondria as has the toxic amyloid beta peptide. The binding site for amyloid beta has been identified as alcohol dehydrogenase in the matrix space of the organelle.

This enzyme can metabolize aldehydes and if the function is impaired could be involved in generation of oxidative radicals and a consequent cell death. Another mitochondrial protein implicated in Alzheimer's Disease is pyruvate dehydrogenase.


Complex IV Enzyme Activity Assays
Cat. No. Name Reactivity Amount Price  
MS441 Complex IV Human Enzyme Activity Microplate Assay Kit human, bovine 96 tests $425.00
MS443 Complex IV Human Duplexing (Activity + Quantity) Microplate Assay Kit human, bovine 96 tests $495.00
MS444 Complex IV Rodent Enzyme Activity Microplate Assay Kit mouse, rat 96 tests $425.00
MS430 Complex IV Human Enzyme Activity Dipstick Assay Kit human, bovine 30 tests $325.00
90 tests $595.00
MS432 Complex IV Rodent Enzyme Activity Dipstick Assay Kit mouse, rat 30 tests $325.00
90 tests $595.00


Complex IV Protein Quantity Assays
Cat. No. Name Reactivity Amount Price  
MSFX-4 Complex IV FlexPlex™ Module human 4 strips (32 tests) $125.00
MS443 Complex IV Human Duplexing (Activity + Quantity) Microplate Assay Kit human, bovine 96 tests $495.00
MS431 Complex IV Human Protein Quantity Dipstick Assay Kit human, bovine 30 tests $325.00
90 tests $595.00



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