Alpha-enolase (ENO1)

UniProt Number: P06733
Alternate Names: 2-phospho-D-glycerate hydro-lyase, C-myc promoter-binding protein, Enolase 1, MBP-1, MPB-1, Non-neural enolase, Short name=NNE, Phosphopyruvate hydratase, Plasminogen-binding protein
Structure and Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.

Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to Cytoplasm. Cell membrane. Cytoplasm myofibril sarcomere M line.

MBP1, a shorter isoform of the ENO1, binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. It locates mainly in nucleus.
Disease Associations: Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid replacement leading to hypothyroidism.

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount
MS951 ENO1 antibody human IP, ICC, ICE, FLOW 100 µg

Enzyme Activity Assays
Cat. No. Name Reactivity Amount
MS988 ENO1 Human Activity Assay Kit (ab117994) human 96 tests

Protein Quantity Assays
Cat. No. Name Reactivity Amount
MS973 ENO1 Human ELISA Kit (ab116694) human 96 tests

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