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Vacuolar protein sorting/targeting protein VPS10

UniProt Number: P00560
Alternate Names: PEP1, Carboxypeptidase Y receptor
Short name=CPY receptor
Carboxypeptidase Y-deficient protein 1
Sortilin VPS10
Vacuolar carboxypeptidase sorting receptor VPS10
Vacuolar protein sorting-associated protein 10
Vacuolar protein-targeting protein 1
Structure and Function:

Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. May execute multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment. Binds the Golgi-modified P2 form of CPY, and this interaction is dependent on the presence of an intact CPY vacuolar protein sorting signal.

Disease Associations:  

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount
MSZ09 VPS10 antibody Yeast WB 250 µg

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