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UDP-glucuronosyltransferase (UGT)

UniProt Number: P22309(UGT1A1), P35503(UGT1A3), P22310(UGT1A4), P35504(UGT1A5, P19224(UGT1A6), Q9HAW7(UGT1A7), O60656(UGT1A9), P06133(UGT2B4), P16662(UGT2B7), P36537(UGT2B10), O75310 (UGT2B11), O75795 (UGT2B17),
Alternate Names: UDP-glucuronosyltransferase
Structure and Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Disease Associations: A deficiency in the bilirubin specific form of glucuronosyltransferase is thought to be the cause of Gilbert's syndrome, which is characterized by unconjugated hyperbilirubinemia. It is also associated with Crigler-Najjar syndrome, a more serious disorder where the enzyme's activity is either completely absent (Crigler-Najjar syndrome type I) or less than 10% of normal (type II). Infants may have a developmental deficiency in UDP-glucuronyl transferase, and are unable to hepatically metabolize the antibiotic drug chloramphenicol which requires glucuronidation. This leads to a condition known as Gray baby syndrome.

Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount
ab129729 Pan-UGT antibody [7H2AF11] human ICC, IP, ICE 100 µg

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