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SRA stem-loop-interacting RNA-binding protein, mitochondrial
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UniProt Number:
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Q9GZT3
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Alternate Names:
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SLIRP, C14orf156
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Structure and Function:
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SLIRP is a RNA binding protein that acts as a nuclear receptor corepressor. It may act by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. SLIRP binds the STR7 loop of SRA RNA. It is also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. It contains 1 RRM (RNA recognition motif) domain. SLIRP is predominantly founs in mitochondrial with a limited role in the nucleus where it is recruited to nuclear receptor target promoters.
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Disease Associations:
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n/a
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Monoclonal Antibodies
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