Histone H2A.x (H2AX)

UniProt Number: P16104
Alternate Names: H2A.x
Structure and Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Phosphorylated on Ser-140 (to form gamma-H2AFX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, and may also occur during meiotic recombination events and immunoglobulin class switching in lymphocytes.
Disease Associations:  

Antibody Cocktails
Cat. No. Name Reactivity Amount
ab131385 Anti-GAPDH + H2A.X(S139) +cleaved-PARP antibody [3E8, 9F3 and 4B5] Human 10 Blots

In-Cell ELISA Kits
Cat. No. Name Reactivity Amount
ab131382 H2A.X (pSer139) Human In-Cell ELISA Kit (IR) Human 96 Tests
ab131383 H2A.X (pSer139) + Cleaved-PARP Human In-Cell ELISA Kit (IR) Human 96 Tests

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