Proteins > Glycogen synthase kinase-3 beta (GSK3B)
Glycogen synthase kinase-3 beta (GSK3B)
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UniProt Number:
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P42212 |
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Alternate Names:
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GSK3B |
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Structure and Function:
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Glycogen synthase kinase-3 (GSK-3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and an inactivating agent of glycogen synthase. Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.
Phosphorylated by AKT1. Upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and deactivates GSK3B, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-216.
The phosphorylated form shows localization to cytoplasm and cell membrane.
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.
Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. |
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Disease Associations:
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Protein Quantity Assays
In-Cell ELISA Kits
Flow Cytometry Kits
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