5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK alpha 1

UniProt Number: Q13131
Alternate Names: PRKAA1, AMPK1, Acetyl-CoA carboxylase kinase, Hydroxymethylglutaryl-CoA reductase kinase
Structure and Function: 5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme that plays a role in cellular energy homeostasis. AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. AMPK also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxy methylglutaryl-CoA reductase. AMPK ppears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK1 is the catalytic subunit and is activated by phosphorlation.
Disease Associations: Involved in numerous metabolic diseases.

Protein Quantity Assays
Cat. No. Name Reactivity Amount
ab140358 AMPK alpha 1 ELISA human,mouse,rat 96 tests
ab154468 AMPKα (pT172) ELISA Kit human,mouse,rat 96 tests
ab157397 AMPKa pSer496 ELISA Kit human 96 tests

In-Cell ELISA Assays
Cat. No. Name Reactivity Amount
ab151280 AMPKα Total & pT183/T172 ICE Kit (IR) human,mouse,rat 96 tests

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