Proteins > A5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK alpha 1
5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK alpha 1
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UniProt Number:
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Q13131
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Alternate Names:
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PRKAA1, AMPK1, Acetyl-CoA carboxylase kinase, Hydroxymethylglutaryl-CoA reductase kinase
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Structure and Function:
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5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme that plays a role in cellular energy homeostasis.
AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. AMPK also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxy methylglutaryl-CoA reductase. AMPK ppears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK1 is the catalytic subunit and is activated by phosphorlation.
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Disease Associations:
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Involved in numerous metabolic diseases.
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Protein Quantity Assays
In-Cell ELISA Assays
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