Images:
Figure 1. PDH subunit E2 Western blotting image.
Figure 2. PDH subunit E2 Immunocytochemistry image.
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PDH subunit E2 monoclonal antibody
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Catalog No. MSP05
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$325.00 - 100 µg
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UniProt Number:
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P10515
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Alternate Names:
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Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, M2 antigen complex 70 kDa subunit, Pyruvate dehydrogenase complex E2 subunit (Short name=PDC-E2), (Short name=PDCE2), (Short name=E2) Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex 70 kDa mitochondrial autoantigen of primary biliary cirrhosis (Short name=PBC)
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Structure and Function:
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The pyruvate dehydrogenase complex contains three different subunits including the dihydrolipoamide acetyltransferase (E2) subunit.
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Disease Associations:
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The E2 subunit of the PHD complex is associated with primary biliary cirrhosis in that patients diagnosed with this disease have autoantibodies for this subunit. This condition causes damage to liver cells and can result in cirrhosis of the liver. Lactic acidemia (PDH deficiency) is another condition associated with the E2 subunit. The clinical characterization of this disorder includes primary lactic acidosis as well as neurological problems, mainly episodic dystonia.
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