MitoSciences takes pride in contributing to mitochondrial research. Below is a listing of recent publications that MitoSciences senior researchers and other members of our research team have authored or to which they have contributed.


1. Shikuma CM, Gerschenson M, Chow D, Libutti DE, Willis JH, Murray J, Capaldi RA, Marusich M. (2008) "Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status." AIDS Research and Human Retroviruses. October 1, 24(10): 1255-1262.

2. Murray J, Oquendo CE, Willis JH, Marusich MF, Capaldi RA. (2008) "Monitoring oxidative and nitrative modification of cellular proteins; a paradigm for identifying key disease related markers of oxidative stress." Advanced Drug Delivery Reviews, Volume 60, Issues 13-14, October-November 2008, Pages 1497-1503.

3. Willis JH, Isaya G, Gakh O, Capaldi RA, Marusich MF. (2008) "Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers." Molecular Genetics and Metabolism, Volume 94, Issue 4, August 2008, Pages 491-497.

4. Dykens J, Jamieson J, Marroquin L, Nadanaciva S, Xu J, Dunn M, Smith A, Will Y. (2008) "In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone and Buspirone." Tox Sci. doi:10.1093/toxsci/kfn056.

  2007

1. Baden K, Murray J, Capaldi R, Guillemin K. (2007) "Early Development Pathology Due to Cytochrome c Oxidase Deficiency is Revealed by a New Zebrafish Model." J Bio Chem. 282(48): 34839-49.

2. Nadanaciva S, Dykens J, Bernal A, Capaldi R. (2007) "Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration." Tox and Applied Pharma. 223(3): 277-87.

3. Hajek P, Chomyn A, Attardi G. (2007) "Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2." J. Biol. Chem. 282(8): 5670-81.

4. Murray J, Schilling B, Row RH, Yoo CB, Gibson BW, Marusich MF, Capaldi RA. (2007 in press) "Small-scale immunopurification of cytochrome c oxidase for a high throughput, multiplexing analysis of enzyme activity, and amount." Biotech. and Applied Biochem.

5. Nadanaciva S, Bernal A, Aggeler R, Capaldi R, Will Y. (2007) "Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays." Toxicol In Vitro. 21(5): 902-11.

6. Xie J, Marusich MF, Souda P, Whitelegge J, Capaldi RA. (2007) "The mitochondrial inner membrane protein Mitofilin exists as a complex with SAM50, metaxin 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11" (submitted)

  2006

1. Guan MX, Yan Q, Li X, Bykhovskaya Y, Gallo-Teran J, Hajek P, Umeda N, Zhao H, Garrido G, Mengesha E, Suzuki T, del Castillo I, Peters JL, Li R, Qian Y, Wang X, Ballana E, Shohat M, Lu J, Estivill X, Watanabe K, Fischel-Ghodsian N. "Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations." Amer. J. Hum. Genet. 79(2): 291-302.

2. Hagiwara M, Yamagata K, Capaldi RA, Koyama A. (2006) "Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis." Kidney Int. 69(7): 1146-52.

3. Keeney PM, Xie J, Capaldi RA, Bennett JP Jr. (2006) "Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled." J. Neurosci. 26(19): 5256-64.

4. Schilling B, Murray J, Yoo CB, Row RH, Cusack MP, Capaldi RA, Gibson BW. (2006) "Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria." Biochim. Biophys. Acta. 1762(2): 213-22.

5. Walker DW, Hajek P, Muffat J, Knoepfle D, Cornelison S, Attardi G, Benzer S. (2006) "Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant." Proc. Natl. Acad. Sci. USA. 103(44): 16382-7.

6. Willis JH, Munro E, Lyczak R, Bowerman B. (2006) "Conditional dominant mutations in the Caenorhabditis elegans gene act-2 identify cytoplasmic and muscle roles for a redundant actin isoform." Mol. Biol. Cell. 17(3): 1051-64.

7. Yonally SK, Capaldi RA. (2006) "The F(1)F(0) ATP synthase and mitochondrial respiratory chain complexes are present on the plasma membrane of an osteosarcoma cell line: An immunocytochemical study." Mitochondrion. 6: 305-14.

  2005

1. Burwick NR, Wahl ML, Moser TL, Li B, Capaldi RA, Kenan DJ, Pizzo SV. (2005) "An inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface." J. Biol. Chem. 280: 1740-5.

2. Encalada SE, Willis JH, Lyczak R, Bowerman B. (2005) "A spindle checkpoint functions during mitosis in the early Caenorhabditis elegans embryo." Mol. Biol. Cell. 16(3): 1056-70.

3. Schilling B, Aggeler R, Schulenberg B, Murray J, Row RH, Capaldi RA, Gibson BW. (2005) "Mass spectrometric identification of a novel phosphorylation site in subunit NDUFA10 of bovine mitochondrial complex I." FEBS Lett, 579: 2485-90.

4. Schilling B, Bharath S, Row RH, Murray J, Capaldi RA, Freed CR, Prasad KN, Andersen JK, Gibson BW. (2005) "Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and dopaminergic neuronal cell line." Mol. Cell Proteomics. 4: 84-96.

5. Slemmon JR, Painter CL, Nadanaciva S, Catana F, Kaup K, Scherrer R, Casadas V, Zhao Y, and Heron MI. (2005) "Analysis of protein fragmentation inhibition by an MMP-inhibitor in an in vivo model of heart failure using automated chromatography." J. Chromatogr. B. 819(2): 219-28.

  2004

1. Capaldi RA, Murray J, Byrne L, Janes MS, Marusich MF. (2004) "Immunological approaches to the characterization and diagnosis of mitochondrial disease." Mitochondrion. 4: 417-26.

2. Hanson GT, Aggeler R, Oglesbee D, Cannon M, Capaldi RA, Tsien RY, Remington SJ. (2004) "Investigating mitochondrial redox potential with redox sensitive green fluorescent protein indicators." J. Biol. Chem. 279: 13044-53.

3. Janes MS, Hanson BM, Hill DM, Buller GM, Agnew J, Sherwood SW, Cox G, Yamagata K, Capaldi RA. (2004) "Rapid analysis of mitochondrial DNA depletion by fluorescence in situ hybridization and immunocytochemistry: potential strategies for HIV therapeutic monitoring." Hist. Cytochem. 52: 1011-8.

4. Koushika SP, Schaefer AR, Vincent R, Willis JH, Bowerman B, Nonet ML. (2004) "Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo." J. Neurosci. 24(16): 3907-16.

5. Murray J, Marusich MF, Capaldi RA, Aggeler R. (2004) "Focused proteomics: monoclonal antibody-based isolation of the oxidative phosphorylation machinery and detection of phosphoproteins by fluorescent phosphoprotein gel stain." Electrophoresis. 25: 2520-5.

6. Murray J, Yonally S, Aggeler R, Marusich MF, Capaldi RA. (2004) "Focused proteomics: towards a high throughput monoclonal antibody-based resolution of proteins for diagnosis of mitochondrial diseases." Biochim. Biophys. Acta. 1659: 206-11.

7. Oquendo CE, Antonicka H, Shoubridge EA, Reardon W, Brown GK. (2004) "Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome." J. Med. Genet. 41(7): 540-4.

8. Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ, Capaldi RA. (2004) "Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells." Cancer Res. 64: 985-93.

9. Schulenberg B, Goodman TN, Aggeler R, Capaldi RA, Patton WF. (2004) "Characterization of protein phosphorylation using a novel fluorescent phosphoprotein gel stain and mass spectrometry." Electrophoresis. 25: 2526-32.

10. Weber J, Wilke-Mounts S, Nadanaciva S, Senior AE. (2004) "Quantitative determination of direct binding of b subunit to F1 in Escherichia coli F1F0-ATP synthase." J. Biol. Chem. 279(12): 11253-8.