MitoSciences: MSA05 Porin monoclonal antibody

UniProt Number:	Protein (VDAC1): P21796 Protein (VDAC2): P45880 Protein (VDAC3): Q9Y277
Alternate Names:	Outer mitochondrial membrane protein porin 3, Voltage-dependent anion-selective channel protein 3 (Short name=VDAC-3), (Short name=hVDAC3), Outer mitochondrial membrane protein porin 2, Voltage-dependent anion-selective channel protein 2 (Short name=VDAC-2), (Short name=hVDAC2), Porin 31HM, Porin 31HL, Plasmalemmal porin, Outer mitochondrial membrane protein porin 1, Voltage-dependent anion-selective channel protein 1 (Short name=VDAC-1), (Short name=hVDAC1)
Structure and Function:	These three VDAC proteins combine to form a membrane channel that is selective to small hydrophilic molecules. This channel changes conformational state depending on the membrane potential. At low or zero membrane potential the channel is in an open conformation and has a weak affinity for anions. When the membrane potential reaches 30-40mV the channel adopts a closed conformation and is selective to cations. It is also thought that these proteins may contribute to the permeability transition pore complex (PTPC), which releases specific contents of mitochondria resulting in apoptosis.
Disease Associations:	n/a