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Images:


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Figure 1. Isolated mitochondria from human heart (lane 1), bovine heart (lane 2), rat heart (lane 3), mouse heart (lane 4), and HepG2 (lane 5) detected with (MSA05) anti-Porin antibody.



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Figure 2. Skeletal Muscle Immunohistochemistry Tissue sections from a patient with a single large deletion of the mtDNA. Kindly provided by Dr. J. Murphy and D. Turnbull, Mitochondrial Research Group, Newcastle University.



Porin monoclonal antibody

Catalog No. MSA05

$295.00 - 100 µg

UniProt Number: Protein (VDAC1): P21796
Protein (VDAC2): P45880
Protein (VDAC3): Q9Y277
Alternate Names: Outer mitochondrial membrane protein porin 3, Voltage-dependent anion-selective channel protein 3 (Short name=VDAC-3), (Short name=hVDAC3), Outer mitochondrial membrane protein porin 2, Voltage-dependent anion-selective channel protein 2 (Short name=VDAC-2), (Short name=hVDAC2), Porin 31HM, Porin 31HL, Plasmalemmal porin, Outer mitochondrial membrane protein porin 1, Voltage-dependent anion-selective channel protein 1 (Short name=VDAC-1), (Short name=hVDAC1)
Structure and Function: These three VDAC proteins combine to form a membrane channel that is selective to small hydrophilic molecules. This channel changes conformational state depending on the membrane potential. At low or zero membrane potential the channel is in an open conformation and has a weak affinity for anions. When the membrane potential reaches 30-40mV the channel adopts a closed conformation and is selective to cations. It is also thought that these proteins may contribute to the permeability transition pore complex (PTPC), which releases specific contents of mitochondria resulting in apoptosis.
Disease Associations: n/a

Product Specifications
 
Applications: Western blotting, Immunocytochemistry, Immunohistochemistry (heat-induced antigen-retrieval improves signal).
Species Reactivity: human
Host Species: mouse
Isotype: IgG2b, k
Clone ID: 89-173/033
Immunogen: Porin 31HL from EBV-transformed human B lymphocytes
Concentration: 1 mg/mL in 50 mM Tris-HCl, pH 7.0, 50 mM NaOAc, 500 mM NaCl and 0.09% azide as a preservative.
Suggested Working Concentration: 0.5-1.0 g/mL for Immunocytochemistry
Storage Conditions: -20°C
Country of Origin: USA
Citations: Baden et al., 2007. EARLY DEVELOPMENTAL PATHOLOGY DUE TO CYTOCHROME C OXIDASE DEFICIENCY IS REVEALED BY A NEW ZEBRAFISH MODEL.


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