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Figure 1. Isolated mitochondria from human heart (lane 1), bovine heart (lane 2), rat heart (lane 3), mouse heart (lane 4), and HepG2 (lane 5) detected with (MSA03) anti-porin antibody.



Porin monoclonal antibody

Catalog No. MSA03

$295.00 - 100 µg

UniProt Number: Protein (VDAC1): P21796
Protein (VDAC2): P45880
Protein (VDAC3): Q9Y277
Alternate Names: Outer mitochondrial membrane protein porin 3, Voltage-dependent anion-selective channel protein 3 (Short name=VDAC-3), (Short name=hVDAC3), Outer mitochondrial membrane protein porin 2, Voltage-dependent anion-selective channel protein 2 (Short name=VDAC-2), (Short name=hVDAC2), Porin 31HM, Porin 31HL, Plasmalemmal porin, Outer mitochondrial membrane protein porin 1, Voltage-dependent anion-selective channel protein 1 (Short name=VDAC-1), (Short name=hVDAC1)
Structure and Function: These three VDAC proteins combine to form a membrane channel that is selective to small hydrophilic molecules. This channel changes conformational state depending on the membrane potential. At low or zero membrane potential the channel is in an open conformation and has a weak affinity for anions. When the membrane potential reaches 30-40mV the channel adopts a closed conformation and is selective to cations. It is also thought that these proteins may contribute to the permeability transition pore complex (PTPC), which releases specific contents of mitochondria resulting in apoptosis.
Disease Associations: n/a

Product Specifications
 
Applications: Western blotting
Species Reactivity: human, bovine, rat, mouse (two bands) and Drosophila melanogaster
Host Species: mouse
Isotype: IgG2b, k
Clone ID: 20B12AF2
Immunogen: Human full length recombinant mature Porin protein
Concentration: 1 mg/mL in Hepes-Buffered Saline (HBS) with 0.02% azide as a preservative.
Suggested Working Concentration: 1 g/mL for Western blotting
Storage Conditions: 4°C
Country of Origin: USA
Citations: Sun et al., 2007. Mitochondrial dysfunction precedes neurodegeneration in mahogunin (Mgrn1) mutant mice.

Toroser et al., 2007. Carbonylation of mitochondrial proteins in Drosophila melanogaster during aging.

Li et al., 2007. An Assembled Complex IV Maintains the Stability and Activity of Complex I in Mammalian Mitochondria.

Fernandez-Vizarra et al., 2007. Impaired complex III assembly associated with BCS1L gene mutations in isolated mitochondrial encephalopathy.

Dell'Agnello et al., 2007. Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice.

Pye et al., 2006. Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants.


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