MitoSciences: NAD-dependent deacetylase sirtuin 1 (SIRT1)

UniProt Number:	Q96EB6
Alternate Names:	SIR2-like protein 1, SIR2L1
Structure and Function:	SIRT1 - silent mating type information regulation 2 homolog - (homolog of yeast Sir2) is a member of the sirtuins family of deacetylases. SIRT1 is responsible for epigenetic gene silencing after recruitment to the nucleus. Sirtuin1 deactylates proteins, including histones, in a wide (and growing) variety of processes in apoptosis and senescence, muscle differentiation and may serve as a cytosolic NAD+/NADH sensor. This enzyme may also regulate the circadian clock of the cell in response to metabolic conditions. Sirtuin is inhibited by nicotinamide and may be activated by resveratrol, a component of red wine. Resveratrol may participate in activation of sirtuin proteins, and may therefore participate in an extended lifespan as it has been observed in yeast. Inhibited by nicotinamide. Activated by resveratrol (3,5,4'-trihydroxy-trans-stilbene), butein (3,4,2',4'-tetrahydroxychalcone), piceatannol (3,5,3',4'-tetrahydroxy-trans-stilbene), Isoliquiritigenin (4,2',4'-trihydroxychalcone), fisetin (3,7,3',4'-tetrahydroxyflavone) and quercetin (3,5,7,3',4'-pentahydroxyflavone). RPS19BP1/AROS acts as a positive regulator of deacetylation activity. Negatively regulated by KIAA1967/DBC1.
Disease Associations:	n/a