Figure 2. Skeletal muscle immunohistochemistry using MS408- fixed frozen tissue sections from a patient with a single large deletion of the mtDNA. All muscle fibers express subunit IV of complex IV because this subunit is encoded by nuclear DNA and persists in a partial complex in the absence of mtDNA-encoded subunits. Image kindly provided by Dr. J. Murphy and D. Turnbull, Mitochondrial Research Group, Newcastle University.

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