Complex IV


Alternate Names: cytochrome c oxidase, cytochrome oxidase, cytochrome c oxidoreductase
Structure and Function: Complex IV is a complex of 13 different subunits, 3 of which (I, II and III) are encoded on mtDNA, with the remainder nuclear-encoded. The complex contains 2 heme groups (a and a3) and 2 copper atoms as prosthetic groups.
Disease Associations: Genetic alterations of this enzyme complex are a common cause of OXPHOS diseases. The enzyme is altered in Alzheimer's disease, and there are reports of reduced amounts of this complex in cancer cells when these cells become hypoxic.


Monoclonal Antibodies
Cat. No. Name Reactivity Apps. Amount
MS401c Complex IV
capture antibody
Human, Bovine IP 100 µg
MS404 Complex IV
subunit I
Human, Bovine, Mouse, Rat, Zebrafish, C. elegans, oyster WB, ICC, ICE, FLOW, BNPAGE 100 µg
ab154477 MTCO1 antibody (Alexa Fluor® 488) Human, Bovine, Mouse, Rat, Zebrafish, C. elegans ICC/IF, FLOW 100 µg
MS418 Complex IV
subunit I (Cox1p)
S. cerevisiae WB 100 µg
MS405 Complex IV
subunit II
Human WB, ICC, FLOW 100 µg
MS419 Complex IV
subunit II (Cox2p)
S. cerevisiae WB 100 µg
ab156031 MTCO2 [MM7D-5A11CA9] antibody Human, Monkey WB, ICC, Flow Cyt, IP 100 µg
MS406 Complex IV
subunit III
Human, Rat, Mouse, S. cerevisiae WB 100 µg
MS407 Complex IV
subunit IV
Human, Bovine, Mouse, Rat, Zebrafish WB, BNPAGE 100 µg
MS408 Complex IV
subunit IV
Human, Bovine WB, ICC, FLOW 100 µg
MS420 Complex IV
subunit IV (Cox4p)
S. cerevisiae WB 100 µg
MS409 Complex IV
subunit Va
Human, Bovine, Mouse, Rat, Zebrafish WB, ICC, FLOW 100 µg
MS410 Complex IV
subunit Vb
Human, Bovine, Mouse, Rat WB 100 µg
MS411 Complex IV
subunit VIaH
Bovine WB 250 µg
MS412 Complex IV
subunit VIaL
Liver isoform in Human, Rat, Mouse WB 250 µg
MS413 Complex IV
subunit VIb
Human, Bovine, Rat WB 100 µg
MS414 Complex IV
subunit VIc
Human, Bovine, Rat WB 100 µg
MS415 Complex IV
subunit VIIaHL
Bovine, Rat WB 250 µg
MS416 Complex IV
subunit VIIb
Bovine WB 250 µg
MS403 Complex IV
subunit SURF1
Human WB 100 µg


Protein Quantity Assays
Cat. No. Name Reactivity Amount
ab124538 Cytochrome-C Oxidase (Complex IV) Human Profiling ELISA Kit (MS1038) Human 96 Tests
MS443 Complex IV Human Duplexing (Activity + Quantity) Microplate Assay Kit Human, Bovine 96 Tests
MS431 Complex IV Human Protein Quantity Dipstick Assay Kit Human, Bovine 30 Tests
90 Tests


One Step Protein Quantity Assays
Cat. No. Name Reactivity Amount
ab179880 Cytochrome-c Oxidase (Complex IV) Human ELISA Kit Human 96 Tests


Enzyme Activity Assays
Cat. No. Name Reactivity Amount
MS441 Complex IV Human Enzyme Activity Microplate Assay Kit Human, Bovine 96 Tests
MS443 Complex IV Human Duplexing (Activity + Quantity) Microplate Assay Kit Human, Bovine 96 Tests
MS444 Complex IV Rodent Enzyme Activity Microplate Assay Kit Mouse, Rat 96 Tests
MS430 Complex IV Human Enzyme Activity Dipstick Assay Kit Human, Bovine 30 Tests
90 Tests
MS432 Complex IV Rodent Enzyme Activity Dipstick Assay Kit Mouse, Rat 30 Tests
90 Tests


Multiplexing Arrays
Cat. No. Name Reactivity Amount
MSX31 MetaPath™ MitoDisease
4-Plex Dipstick Array
Human 30 Tests
90 Tests


Enzyme Purification Kits
Cat. No. Name Reactivity Amount
MS401 Complex IV Human Immunocapture Kit Human, Bovine 250 µg
500 µg
750 µg
MS402 Complex IV Rodent Immunocapture Kit Mouse, Rat 250 µg
500 µg
750 µg



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