Images:
(click to enlarge)
Figure 1. Isolated mitochondria from human heart (lane 1), bovine heart (lane 2), rat heart (lane 3), mouse heart (lane 4), and HepG2 (lane 5) detected with (MS304) anti-Core 2 antibody.
Figure 2. ICC Image
(click to enlarge)
Figure 3. Colon Immunohistochemistry – Tissue sections from a normal ageing patient. Kindly provided by Dr. L. Greaves and D. Turnbull, Mitochondrial Research Group, Newcastle University. For more details, see Taylor et al., J. Clin. Invest. 112:1351-1360 (2003)
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Complex III subunit Core 2 monoclonal antibody
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Catalog No. MS304
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$295.00 - 100 µg
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UniProt Number:
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P22695
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Alternate Names:
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Cytochrome b-c1 complex subunit 2, mitochondrial, Ubiquinol-cytochrome-c reductase complex core protein 2, Core protein II, Complex III subunit 2
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Structure and Function:
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Core protein 2 ((UQCR2/QCR2) is a subunit of complex III, a component of the ETC responsible for transferring electrons from coenzyme Q to cytochrome c. Complex III consists of 11 subunits, two of which are core proteins. The core protein 2 subunit of complex III is necessary for formation of the complex.
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Disease Associations:
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n/a
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Product Specifications
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Applications:
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Western blotting, Immunocytochemistry, Immunohistochemistry (heat-induced antigen-retrieval improves signal).
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Species Reactivity:
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human, bovine, rat, mouse
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Host Species:
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mouse
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Isotype:
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IgG1, k
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Clone ID:
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13G12AF12BB11
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Immunogen:
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Bovine Heart Complex III
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Concentration:
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1 mg/mL in HEPES-Buffered Saline (HBS) with 0.02% azide as a preservative.
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Suggested Working Concentration:
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1 µg/mL for Western blotting, 0.1-0.5 µg/mL for Immunocytochemistry
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Storage Conditions:
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4°C
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Country of Origin:
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USA
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Citations:
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Khidr et al., 2008. Role of SUV3 Helicase in Maintaining Mitochondrial Homeostasis in Human Cells.
Fornuskova et al., 2008. The impact of mitochondrial tRNA mutations on the amount of ATP synthase differs in the brain compared to other tissues.
Huffman et al., 2008. Effect of exercise and calorie restriction on biomarkers of aging in mice.
Dasgupta et al., 2008. Mitochondrial Cytochrome B Gene Mutation Promotes Tumor Growth in Bladder Cancer.
Bastin et al., 2008. Activation of peroxisome proliferator activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components.
Pagel-Langenickel et al., 2007. A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in Type 2 diabetes mellitus.
Saelim et al., 2007. Inhibition of apoptotic potency by ligand stimulated thyroid hormone receptors located in mitochondria.
Lebon et al., 2007. A novel mutation of the NDUFS7 gene leads to activation of a cryptic exon and impaired assembly of mitochondrial complex I in a patient with Leigh syndrome.
Ramanujan et al., 2007. Aging Process Modulates Nonlinear Dynamics in Liver Cell Metabolism.
Park et al., 2006. Yeast NDI1 improves oxidative phosphorylation capacity and increases protection against oxidative stress and cell death in cells carrying a Leber's hereditary optic neuropathy mutation.
Li et al., 2006. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex.
Pye et al., 2006. Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants.
Wall et al., 2006. ALTERATIONS IN OXIDATIVE PHOSPHORYLATION COMPLEX PROTEINS IN THE HEARTS OF TRANSGENIC MICE THAT OVEREXPRESS THE p38 MAP KINASE ACTIVATOR, MAP KINASE KINASE 6.
Schrauwen et al., 2006. Reduced Skeletal Muscle Uncoupling Protein-3 Content in Prediabetic Subjects and Type 2 Diabetic Patients: Restoration by Rosiglitazone Treatment.
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