Complex III subunit Core 1 monoclonal antibody
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Catalog No. MS303
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$325.00 - 100 µg
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This antibody can also be purchased as part of a Sample Pack.
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UniProt Number:
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P31930
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Alternate Names:
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Cytochrome b-c1 complex subunit 1, mitochondrial, Ubiquinol-cytochrome-c reductase complex core protein 1 (Short name=Core protein I) Complex III subunit 1
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Structure and Function:
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Core protein 1 is a subunit of complex III, a component of the ETC responsible for transferring electrons from coenzyme Q to cytochrome c. Complex III consists of 11 subunits, two of which are core proteins. Core protein 1 (UQCR1/QCR1) is thought to mediate the connection between the cytochrome c1 subunit and cytochrome c.
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Product Specifications
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Applications:
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Western blotting
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Species Reactivity:
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human, bovine, rat, mouse
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Host Species:
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mouse
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Isotype:
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IgG1, κ
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Clone ID:
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16D10AD9AH5
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Concentration:
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1 mg/mL in Hepes-Buffered Saline (HBS)-Buffered Saline (HBS) with 0.02% azide as a preservative.
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Suggested Working Concentration:
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0.5 µg/mL for Western blotting
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Storage Conditions:
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Store at 4°C. Do not freeze.
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Country of Origin:
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USA
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WB Images
(click to enlarge)
Figure 1. Isolated mitochondria from human heart (lane 1), bovine heart (lane 2), rat heart (lane 3), mouse heart (lane 4), and HepG2 (lane 5) detected with (MS303) anti-Core 1 antibody. Extra bands in the mouse sample (lane 4) are due to the reaction of the IgG-specific goat anti-mouse secondary antibody with residual mouse blood in the heart tissue, as it is very difficult to entirely remove the blood from these small organs.
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Published Studies Using This Product:
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Kotarsky et al., 2010. Characterization of complex III deficiency and liver dysfunction in GRACILE syndrome caused by a BCS1L mutation.
Mayr et al., 2010. Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1 {varepsilon} subunit.
Fogal et al., 2010. Mitochondrial p32 Protein is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation.
Frier et al., 2009. The effects of apelin treatment on skeletal muscle mitochondrial content.
Son et al., 2009 Redox susceptibility of SOD1 mutants is associated with the differential response to CCS over-expression in vivo.
Hu et al., 2009. Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose.
Leary et al., 2009. Oxidative phosphorylation: synthesis of mitochondrially encoded proteins and assembly of individual structural subunits into functional holoenzyme complexes.
Ahn et al., 2008. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
Son et al., 2008. Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein.
Minai et al., 2008. Mitochondrial respiratory chain complex assembly and function during human fetal development.
Pravenec et al., 2007. Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains.
Wang et al., 2006. Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane.
Kriaucionis et al., 2006. Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome.
Honzík et al., 2006. Specific properties of heavy fraction of mitochondria from human-term placenta - glycerophosphate-dependent hydrogen peroxide production.
Mrácek et al., 2005. Time-course of hormonal induction of mitochondrial glycerophosphate dehydrogenase biogenesis in rat liver.
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