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Figure 1. Isolated mitochondria from human heart (lane 1), bovine heart (lane 2), rat heart (lane 3), and mouse heart (lane 4) detected with (MS306) anti-10kDa antibody.

Complex III subunit 10 kDa monoclonal antibody

Catalog No. MS306

$295.00 - 100 µg

UniProt Number: O14949
Alternate Names: Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C, Cytochrome b-c1 complex subunit 8, Ubiquinol-cytochrome c reductase complex 9.5 kDa protein, Complex III subunit VIII, Complex III subunit 8
Structure and Function: Complex III, a component of the ETC, is responsible for transferring electrons from coenzyme Q to cytochrome c. It contains 11 subunits, subunit 8 (UQCRQ/QCR8) is one of the 6 small protein subunits. Subunit 8 and cytochrome b subunit bind, which then bind ubiquinone together.
Disease Associations: Abnormalities in complex III cause complex III deficiency, which can cause extremely uncoordinated voluntary movements, dystonia, athetoid movements, ataxia, mild axial hypotonia, increased tone, hyperreflexia, and inability to walk without support. The activity level of mitochondrial complex III in muscle decreases and serum lactate levels slightly increase.

Product Specifications
Applications: Western blotting
Species Reactivity: human, bovine, rat, mouse
Host Species: mouse
Isotype: IgG2a, k
Clone ID: 1H9DE5DG5BC8
Immunogen: Bovine Complex III
Concentration: 1 mg/mL in HEPES-Buffered Saline (HBS) with 0.02% azide as a preservative.
Suggested Working Concentration: 1 g/mL for Western blotting
Storage Conditions: 4°C
Country of Origin: USA
Citations: Fernandez-Vizarra et al., 2007. Impaired complex III assembly associated with BCS1L gene mutations in isolated mitochondrial encephalopathy.

Dykens et al., 2007. Strategies to reduce late-stage drug attrition due to mitochondrial toxicity.

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