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Complex I
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Alternate Names:
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NADH dehydrogenase, NADH ubiquinone oxidoreductase
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Structure and Function:
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Complex I is a large protein complex of 950,000 MW made up of 45-46 different subunits. A total of 7 of the subunits of the complex are encoded on mtDNA, the remainder are nuclear encoded, made in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyses electron entry from NADH, as the name implies, via a flavin (FMN) and several non-heme iron centers.
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Disease Associations:
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Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson's disease and schizophrenia. Also there is evidence of Complex I involvement in diabetes.
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Monoclonal Antibodies
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Cat. No.
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Name
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Reactivity
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Apps.
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Amount
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Price
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MS101c
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Complex I
capture antibody
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Human, Mouse, Rat, Bovine
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IP, ICC, ICE, FLOW
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100 µg
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$325.00
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MS109
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Complex I
subunit 8 kDa
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Human, Mouse, Rat, Bovine
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WB
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100 µg
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$325.00
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MS103
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Complex I
subunit GRIM-19
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Human, Mouse, Rat, Bovine
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WB, ICC, ICE, FLOW, BNPAGE
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100 µg
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$325.00
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MS111
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Complex I
subunit NDUFA9
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Human, Mouse, Rat, Bovine
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WB, BNPAGE
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100 µg
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$325.00
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MS107
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Complex I
subunit NDUFB4
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Human, Rat, Bovine
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WB, ICC, FLOW
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100 µg
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$325.00
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MS108
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Complex I
subunit NDUFB6
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Human, Mouse, Rat, Bovine
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WB
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100 µg
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$325.00
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MS105
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Complex I
subunit NDUFB8
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Human, Mouse, Rat, Bovine
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WB, BNPAGE
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100 µg
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$325.00
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MS114
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Complex I
subunit NDUFS2
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Human
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WB, ICC
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100 µg
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$325.00
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MS110
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Complex I
subunit NDUFS3
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Human, Mouse, Rat, Bovine, Zebrafish
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WB, ICC, IHC, FLOW
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100 µg
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$325.00
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MS112
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Complex I
subunit NDUFS3
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Human, Mouse, Rat, Bovine, Zebrafish, Drosophila, C. elegans
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WB
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100 µg
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$325.00
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MS104
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Complex I
subunit NDUFS4
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Human, Mouse, Rat, Bovine
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WB
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100 µg
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$325.00
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Enzyme Activity Assays
Protein Quantity Assays
Multiplexing Arrays
Enzyme Purification Kits
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Related Pathways:
Apoptosis
Oxidative Phosphorylation
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