MitoSciences: Calnexin (CANX)

UniProt Number:	P27824
Alternate Names:	IP90, Major histocompatibility complex class I antigen-binding protein p88, p90
Structure and Function:	Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin is one of the chaperone molecules, which are characterized by their main function of assisting protein folding and quality control, ensuring that only properly folded and assembled proteins proceed further along the secretory pathway. ATP and calcium ions are two of the cofactors involved in substrate binding for calnexin.
Disease Associations:	n/a