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MitoProfileŽ Biogenesis Dipstick Assay Kit

Catalog No. MS631

$375.00 - 30 tests

Product Description

The MitoProfileŽ Biogenesis Dipstick Assay Kit is used to determine whether mitochondrial biogenesis has been up-regulated or down-regulated as a result of drug interactions or conditions such as oxidative stress and mitochondrial genetic disease.

MS631 is particularly suited for clinical evaluation of mitochondrial toxicity from antibiotic and antiviral drugs (see poster reference below), and has been approved by the FDA as an Investigational Use Only (IUO) device.

Compounds such as resveratrol and regimens such as caloric restriction have also been demonstrated to increase mitochondrial biogenesis in animal studies, and MS631 is suitable for studies of any such up-regulating factors in human cells or patient samples.

The principle of the assay is to compare the levels of Complex IV (cytochrome c oxidase), a mitochondrial enzyme which has 3 subunits encoded by mitochondrial DNA (mtDNA) and made by mitochondrial ribosomes, with that of frataxin, a mitochondrial protein encoded by nuclear DNA and made by cytosolic ribosomes.

Product Specifications
Species Reactivity: human
Storage Conditions: Store the dipsticks and the microplate at room temperature out of direct sunlight in their provided containers.

Store buffers at 4° C, or at -20° C for long term storage.
Country of Origin: USA
Citations: Poster presented at the 8th International Workshop on Adverse Drug Reactions and Lypodystrophy in HIV (2006)

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Click here for a video demonstration of a dipstick assay.

Complementary Product:

Dipstick Reader
Manufactured for us by Hamamatsu, our immunochromatographic reader has been custom configured for our dipsticks. The reader is easy to use and includes software tailored to our assays.

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