ATP synthase


Alternate Names: Complex V, F1F0 ATPase
Structure and Function: ATP synthase is responsible for ATP production in oxidative phosphorylation and can work in reverse as a proton pumping ATPase. The enzyme was thought to be localized exclusively to mitochondria. However, it has recently been identified also on the plasma membrane of several cell types including hepatocytes where it is the HDL receptor, and on endothelial cells where it may act as the angiostatin receptor. The enzyme in mammals is composed of 17 subunits, 5 of which make up the easily detached F1. The remainder are components of 2 stalk domains and the proton pumping F0 part of the machinery. Two of the subunits of the F0 part are encoded on mtDNA while the other subunits are nuclear encoded.
Disease Associations: Mutations in the mt-encoded subunits of ATP synthase (Complex V) cause OXPHOS disease. ATP synthase has also been found on the surface of cancer cells.


Monoclonal Antibodies
Cat. No. Name Reactivity Apps Amount  
MS501c ATP synthase capture antibody Human, Mouse, Rat, Bovine IP 100 µg
MS502 ATP synthase subunit alpha antibody Human, Mouse, Rat, Bovine, Zebrafish WB, ICC, FLOW 100 µg
MS507 ATP synthase subunit alpha antibody Human, Bovine, Rat, Mouse, Drosophila, C. elegans, Oyster WB, ICC, FLOW, BNPAGE 100 µg
ab119688 ATP synthase subunit alpha antibody FITC conjugate Human, Bovine, Rat, Mouse, Drosophila, C. elegans, Oyster WB, ICC, FLOW, BNPAGE 100 µg
MS503 ATP synthase subunit beta antibody Human, Mouse, Rat, Bovine, C. elegans WB, ICC, ICE, FLOW 100 µg
MS511 ATP synthase subunit F1F0 beta antibody Human, Bovine, E. coli WB 100 µg
ab119686 ATP synthase subunit gamma antibody Human, Bovine, Rat, Mouse WB, ICC, ICE, FLOW, IP 100 µg
MS504 ATP synthase subunit d antibody Human, Mouse, Rat, Bovine WB, ICC, FLOW 100 µg
MS508 ATP synthase subunit F6 antibody Human WB, ICC, FLOW 100 µg
MS506 ATP synthase subunit IF1 antibody Human, Mouse, Rat, Bovine WB 100 µg
MS505 ATP synthase subunit OSCP antibody Human, Bovine WB, ICC, FLOW 100 µg
MS972 ATP synthase b subunit antibody Human, Bovine WB, ICC, FLOW 100 µg
ab173006 ATP synthase subunit d antibody Human, Mouse, Rat, Bovine, Cow, African Green Monkey WB, ICC, FLOW 100 µg
ab174438 ATP synthase subunit F-ATPase delta antibody Mouse, Rat, Cow WB 100 µg


Enzyme Activity Assays
Cat. No. Name Reactivity Amount  
MS541 ATP synthase Enzyme Activity Microplate Assay Kit Human, Rat 96 Tests
MS543 ATP synthase Activity+Quantity Duplexing Microplate Assay Kit Human, Rat 96 Tests


Western Blot Cocktails
Cat. No. Name Reactivity Amount  
ab139415 Endoplasmic Reticulum Fraction Western Blot Cocktail Human, Rat 96 Tests


Protein Quantity Assays
Cat. No. Name Reactivity Amount  
ab124539 ATP Synthase (Complex V) Human Profiling ELISA Kit (MS1039) Human 96 Tests
MS543 ATP synthase Activity+Quantity Duplexing Microplate Assay Kit Human, Rat 96 Tests


Enzyme Purification Kits
Cat. No. Name Reactivity Amount  
MS501 ATP synthase
Immunocapture Kit
Human, Mouse, Rat, Bovine 250 µg
500 µg
750 µg


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Oxidative Phosphorylation


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